pcos treatment glp-1 Liraglutide and polycystic ovary syndrome: is it only a matter of body weight? | Journal of Endocrinological Investigation GLP-1 medications emerging as PCOS

Gastrointestinal: acute pancreatitis, hemorrhagic and necrotizing pancreatitis sometimes resulting in death, ileus, intestinal obstruction, severe constipation including fecal impaction Hypersensitivity: anaphylaxis, angioedema Pulmonary: Pulmonary aspiration has occurred in patients receiving GLP-1 receptor agonists undergoing elective surgeries or procedures requiring general anesthesia or deep sedation

7A and B, internal infusion of 10 mol/L U73122 or 60 mol/L D609 for 6 min did not change GABA currents of GCs (control), then addition of exendin-4 for 6 min still suppressed the GABA currents (73.28% 5.09% of control, P 0.05)

This dual mechanism, weight-mediated and insulin-mediated aromatase reduction, may explain why some endometriosis patients see improvements that seem disproportionate to their weight loss alone

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