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Small trials, reports from patients and clinicians, and retrospective studies all point to a powerful anti-addictive effect

Environmental thermal stress (TS) triggers oxidative stress (OS) cascade and deteriorates semen quality and fertilizing potential in rams ( via decrement of the mRNA expression of the mitochondrial superoxide dismutase (SOD)-1 with a subsequent decrease in SOD protein synthesis and activity, and more generation of superoxide anion (SOA) and cell apoptosis ( The positive association between arterial blood flow of the testes and its exocrine (sperm) and endocrine (testosterone hormone) functions has been reported in rams ( via its blood flow measurement ( Digital analysis of the testicular tissue B-mode ultrasound image [testicular echotexture (TE)] has become a useful tool for evaluating the male reproductive functions in different animal species ( Decreased testicular blood perfusion in heat-stress conditions was reported in rams ( via fatty acids (long-chain) transport through mitochondrial membranes and subsequent ATP synthesis via the -oxidation process

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Similarly, A 2A R antagonists or genetic deletion of A 2A R were shown to improve short-term memory, working memory, reversal learning, goal-directed behavior, and fear conditioning in animal models used for different neurological diseases [51-56]