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SAFETY SIGNALS Twenty-eight-day intramuscular dosing in rats and dogs produced what FDA called clinically relevant safety signals: altered activated partial thromboplastin time and liver-associated changes (ALT, glucose, triglycerides)
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Repeat up to 3 times daily
Additional proposed mechanisms include interaction with NMDA receptors and modulation of the stress and HPA axis , the hypothalamic-pituitary-adrenal system that governs the body's stress response
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