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IL-8 mediates neutrophil recruitment and interacts with microglia through autocrine signalling [201]

Qiu J, Bosch MA, Zhang C, Rnnekleiv OK, Kelly MJ

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(Exenatide is FDA approved as monotherapy for the management of T2DM.) Explicitly stated in the guideline for patients requiring dual or triple therapy, the AACE/ACE preferentially recommends the addition of a GLP-1 receptor agonist or a DPP-4 inhibitor (sitagliptin, saxagliptin), citing their efficacy and safety profiles as preferred agents over TZDs or sulfonylureas (SUs)