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For patients without neurological involvement , hydroxocobalamin 1 mg is administered intramuscularly three times a week for 2 weeks, followed by maintenance injections every three months for life (if due to pernicious anaemia or other non-dietary cause)
Carboplatin : Though less ototoxic than cisplatin, carboplatin also affects cochlear hair cells and can cause SHL, particularly at high doses or when used in combination with other chemotherapeutic agents (Funt et al
1A and B, the treatment with epitalon for 4 days was associated with a dose-dependent increase in telomere length starting from the lower concentration of 0.2 to the highest concentration of 1 g/ml in 21NT and BT474
As it develops, not only do B12 levels decrease, but other metabolites or biomarkers of B12 such as holotranscobalamin, methylmalonic acid (MMA), and homocysteine are affected as well
