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While standard GLP-1s can sometimes cause lethargy due to reduced caloric intake, Tesofensine actively increases metabolic rate and often improves patient energy levels and focus

Mechanism of Action Inhibits Nicotinamide N-Methyltransferase (NNMT) Increases intracellular nicotinamide and NAD levels Improves mitochondrial efficiency and energy metabolism Supports lipolysis and fat oxidation Reduces adipocyte (fat cell) growth and proliferation Modulates inflammatory pathways and insulin signaling These effects may lead to enhanced fat metabolism, better blood sugar regulation, improved endurance, and a general increase in metabolic flexibility

The goal is a body that produces energy reliably on its own not one that needs an external boost to function