Less active tyrosinase means less dark pigmentation
acetyl-CoA is the primary substrate for the Krebs cycle, once it is de-acetylated, it must be re-charged with an acetyl-group in order for the Krebs cycle to keep working
For instance, rapamycin-mediated inhibition of mTORC1 has been shown to reduce age-related cancers [19, 20] and age-related declines in cognitive function [21, 22], and to improve heart function [2325], immune function [26], kidney function [27], oral health [28, 29], intestinal function and gut dysbiosis [30, 31], and ovarian function [32] in aging mice
E., Weidler, C., Lerch, K., Hofstadter, F