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Generally, peptide-based therapeutics are challenging to develop due to poor oral bioavailability and susceptibility to metabolic breakdown in vivo

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Evidence reviewed here demonstrates exogenous antioxidants alone produce beneficial effects in various cancers, and except for a few specific cases, animal and human studies demonstrate no reduction of efficacy of chemotherapy or radiation when given with antioxidants

FASEB J (2020) 34(7):892040