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Lysosomal cysteine cathepsins B and L are often overexpressed in aggressive tumors, and upon their transfer to the invadosomes and following secretion to the extracellular space, they can participate in the degradation of the extracellular matrix [46, 48]
Tirzepatide is a dual agonistit activates both GIP and GLP-1 receptors, while semaglutide only activates GLP-1
Adequate selenium intake is mandatory for the normal function of thyrocytes, and selenium deficiency is associated with the decreased synthesis of thyroid hormones (191), increased thyroid volume, and increased number of thyroid nodules (182, 192)
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