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40 Nevertheless, accumulating evidence indicates that CR is detrimental to skeletal metabolism, as evidenced by reductions in BMD and bone mineral content (BMC), diminished bone formation indices (e.g., bone formation rate, osteoblast number), and a concomitant increase in bone resorption
Dosing patterns for hormonal phases While the standard prescribing information for GLP-1 medications like semaglutide or tirzepatide does not include official information for customized dosing based on a patients hormonal phases, there is emerging clinical practice and research focusing on personalized dosing strategies, particularly for women experiencing hormonal shifts
Yet, animals administered with GLP1/GIP or GLP1/E displayed reduced basal glucose levels at the end of treatment (Fig
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