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In a randomized trial of semaglutide 2.4 mg vs placebo for 1 year, 529 participants with HFpEF with a BMI of 30 kg/m2, there was a very large reduction in symptoms, improvement in exercise function in the GLP-1 drug assigned group

Lilly last year said it plans to sell its pill at prices from $149 a month to $399 a month in the cash market, where patients buy drugs directly without using insurance

Endocrinology 146(5):23692375 Krieger JP et al (2016) Knockdown of GLP-1 receptors in vagal afferents affects normal food intake and glycemia

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