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In addition, pharmacokinetic properties such as drug-likeness, gastrointestinal absorption, and blood brain-barrier (BBB) permeability are important to consider when evaluating its ADME profile ( Curcumin exhibits limited bioavailability due to poor gastrointestinal absorption, extensive first-pass metabolism, and rapid systemic clearance
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Therefore, a 1-week washout period was deemed sufficient to prevent carryover effects, consistent with protocols used in similar crossover designs involving acute L-carnitine supplementation
doi: 10.1093/bioinformatics/btq351 32 KuleshovMVJonesMRRouillardADFernandezNFDuanQWangZet al
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