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Specimens were fixed in 10% neutral buffered formalin, processed routinely, and sectioned into 5-micrometer-thick sections

In chronic kidney disease, for example, studies describe a pro-oxidant state driven in part by reduced glutathione and glutathione peroxidase activity meaning the bodys antioxidant defenses are depleted exactly when theyre needed most

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Moreover, it is worth to underline the need of exploring the role of iron-mediated oxidative damage through Fenton reaction to further ascertain the contribution of mitochondrial dysfunction and iron accumulation to the progression and pathologic development of age-related diseases