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In Phase 2 trials, retatrutide was administered as a once-weekly subcutaneous injection using a gradual dose escalation schedule to minimise gastrointestinal side effects

At least 27 new GLP-1 drugs are currently undergoing trials at various stages, including a triple-hormone-receptor agonist combining GLP-1, GIP and glucagon receptors

Tirzepatide, sold under brand names like Mounjaro and Zepbound , is becoming more widely used to treat type 2 diabetes and to help with weight loss