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Priority areas include establishing standardized and quantitative methods for GSH/GSSG measurement and mapping redox heterogeneity across tumor types, as current assays lack spatial and temporal accuracy
Challenges in predicting and optimizing multireceptor agonism Predicting in vivo efficacy of multi-receptor agonists remains a major unresolved challenge, as the pharmacologic activity depends not only on receptor affinity but also on tissue-specific receptor density, distribution, and internalization kinetics
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