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13 We also found tirzepatide produced a 4.87 mm Hg systolic blood pressure reduction, which is consistent with the 4.2 to 5.77 mm Hg reduction in the SURPASS studies

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FoxO1, a downstream target of the PI3K/Akt pathway, is phosphorylated by Akt and retained in the cytoplasm, thereby preventing its inhibition of target gene expression in the nucleus of POMC neurons [17]