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Dietary considerations may play a supportive role, although these are not proven to prevent gallstones in GLP-1 users: Maintain regular meal patterns rather than severely restricting calories, which helps stimulate regular gallbladder contraction Include moderate amounts of healthy fats in the diet (such as olive oil, nuts, and oily fish) to promote gallbladder emptying Ensure adequate hydration to support bile flow Avoid very low-calorie diets unless under specialist supervision For individuals at particularly high risksuch as those with a history of gallstones, rapid weight loss, or multiple risk factorssome specialists may consider ursodeoxycholic acid (UDCA) prophylaxis

Front Endocrinol (Lausanne) (2022) 13:962635

Companies are not allowed to use Section 503A to produce drugs that are essentially copies of a commercially available drug product. However, the FDA has interpreted commercially available to exclude drugs that are on the shortage list

Two independent mechanisms of appetite suppression , in a hypothetical research context, the combination could be supra-additive