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Patients should be informed that having undergone cholecystectomy does not appear to increase their risk of tirzepatide-related adverse effects, though individual tolerance to gastrointestinal side effects may vary based on their post-surgical digestive adaptation

General Principle If nausea is severe at any step, stay at the current dose for an additional 24 weeks before increasing

But higher concentration creates its own challenge

In healthy subjects, subcutaneous injections of GLP-2 elicit a dose-related decrease in CTX-1 (a bone resorption marker), which has sparked suggestions for the use of GLP-2 as a potential osteoporosis treatment [68]