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There are also other practical reasons to prescribe these drugs in people with type 2 diabetes, because all three classes are associated with relatively low risk of hypoglycemic events, while patients treated with GLP-1RA and SGLT-2 inhibitors may also benefit from weight loss [11]
Development and approval of rybelsus (oral semaglutide): ushering in a new era in peptide delivery
Alternative Medications to Consider If semaglutide causes severe acid reflux that you cant manage, your doctor might suggest: A different GLP-1 medicine (like tirzepatide) A lower dose of semaglutide A different type of diabetes or weight loss medicine Combining semaglutide with stronger acid reflux medicines Never stop taking semaglutide without talking to your doctor first
Current estimates indicate that at least one-third of GLP-1 users are taking these drugs exclusively for weight lossnumbers that do not yet account for the new pediatric guidelines
![Once-Monthly Incretin-, Amylin-, and THRβ-Targeting Therapies for Type 2 Diabetes and Obesity: Clinical Evidence and Development Pipelines[v1]](https://www.preprints.org/frontend/manuscript/8f0b88ff05d9221c0624fab564ba2637/download_pub/figure/graphic_abstract.jpg)
