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It was not until the 1960s that technological advances in particular, the radioimmunoassay for insulin developed by Yalow and Berson allowed scientists to clearly demonstrate the incretin effect in humans ( [26] )

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This secret shopper study found that online GLP-1 RA prescription vendors often did not require clinician interaction, relying primarily on patient-reported questionnaires that may not capture important clinical and social history, the study reported