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Real-world effectiveness of tirzepatide versus semaglutide for weight loss in overweight or obese patients in an ambulatory care setting

In both the diabetes and obesity cohorts that got semaglutide, the researchers found that NAION cases occurred most frequently in the first year after the medications were prescribed

Indeed, in humans, SSRIs only elevate serotonin release (and hence activity) moderately, inconsistently, and with a delay (38-40) - which could, in part, explain why SSRIs (and SNRIs) treat depression, OCD, and other mood disorders modestly, inconsistently, and with a delay (41-43)

Some researchers hypothesize that the increased energy expenditure from glucagon activation means less of the caloric deficit needs to come from dietary restriction, which may be less catabolic to muscle tissue