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Older research reviews did not provide modern, well-quantified long-term safety outcomes [1]
After this point, both peptide degradation and bacterial contamination risk increase beyond acceptable thresholds, even with bacteriostatic water as the diluent
In a retrospective study completed by Nadeem et al., it was shown that GLP-1 RAs are associated with an overall fourfold increase in the retention of gastric contents in both diabetic and non-diabetic patients ( p -value 0.8 mL/kg of gastric fluid content (measured from the aspiration/suction canister)
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