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I would not recommend them if you: Are currently pregnant or breastfeeding Have a known active cancer diagnosis (especially hormone-sensitive cancers) Are on immunosuppressive therapy without coordination with your specialist Have a history of severe allergic reactions to peptide-based medications As with all treatments, personalized guidance matters

A Cochrane systematic review of NAC for COPD exacerbations (39 RCTs, n=7,436) found that NAC and other mucolytics significantly reduced the frequency of acute exacerbations (OR 0.75, 95% CI 0.62-0.92) (Poole et al., Cochrane Database Syst Rev, 2019) [43]