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Note that PDE5 inhibitors are absolutely contraindicated with nitrate medications and should be used with caution in patients taking alpha-blockers

To complicate matters, there is some research to suggest GLP-1 agonists may have a role to play in the treatment of binge eating disorders, by curbing appetite and giving people control over their impulse to binge

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These are real medical risk factors that providers consider especially when weight is affecting metabolic health