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Another potential pathway that enhances FXR activity involves the release of the growth factor fibroblast growth factor (FGF) 19 from the intestine upon bile acid binding to FXR, 66 which has shown beneficial effects on MASH in animal models, although results are conflicting

Cabaletta Bio Founded: 2017 Technology / disease area: Autologous CD19 CAR T in autoimmune diseases Lead candidate: rese-cel (formerly CABA-201) Philadelphia-based biotech company Cabaletta Bio is developing autologous CD19-directed CAR T therapies for autoimmune diseases, using an immune reset framing that borrows from oncology CAR T but targets chronic B-cell-driven pathology rather than malignant B cells

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