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The same McCoy 2013 paper reported that Dihexa reversed scopolamine-induced deficits and improved learning in aged rats in the Morris water maze again, animal data, from a paper now carrying an Expression of Concern
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When administered directly into the cerebrospinal fluid of mice, it showed dose-dependent pain-relieving effects that were blocked by naloxone, confirming involvement of opioid pathways
51,56 Zhu et al
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