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The fact that Gcg causes an elevation in blood glucose levels in combination with its limited solubility at a physiological pH has discouraged the use of glucagon as a therapeutic for weight loss

A disruption in your gut microbiome could lead to GI issues like diarrhea, constipation, or bloating each of which is also a side effect of GLP-1 medications

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GLP-1s may help with OA by: Reducing overall inflammation Protecting cartilage in your joints Helping people lose weight takes pressure off the knees and hips Making walking and movement easier over time Studies found that GLP-1 and SGLT2 medicines may lower the risk of needing a knee replacement (for OA), though results varied