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First-pass metabolism occurs when a substance absorbed from the gut passes through the liver first
While the treatment with Ru(II)-OH or NP2 slightly elevated the ROS levels inside the hypoxic cancer cells, the treatment with NP4 showed a strong enhancement of ROS
niacinamide, vitamin C, green tea, & polypodium
doi: 10.1038/s41579-022-00722-z 183 MartinezS
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