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While ruminants can synthesize B 12 via gut bacteria if soil cobalt levels are adequate, monogastric animals like swine and poultry require direct supplementation through fortified feed to maintain health and growth rates in intensive farming environments
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Through pathways such as those involving HIF-1/VEGF, JAK/STAT3, and AKT/mTOR, ROS promote proliferation, survival, angiogenesis, and metabolic adaptation in tumor cells ( Figure 2 )
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