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When available, large, well controlled trials with appropriate statistical methodology were preferred
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Small subunit size catalases have the ability to bind NADP(H) cofactor which is not essential for the activity of catalase [36], but it is believed to have a role in protecting the enzyme from the formation of catalytically inactive intermediate (cpd II) by promoting its reduction to resting state (Fe 3+ ) during catalytic cycle [37, 38]
All while navigating the inevitable political backlash over the cost of these drugs (not something to ignore after they passed the Inflation Reduction Act and are even talking about march-in-rights on patents!)
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