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Endurance athletes and outdoor workers face the highest risk of over-drinking water without electrolytes
The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking
Sexton DJ et al
Grxs depend on reduced GSH for reduction of their active site
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