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Endocrine disorders such as MEN 2 (Multiple Endocrine Neoplasia type 2 syndrome) Due to the potential risk for thyroid cancer, you should not use tirzepatide if you have a personal or family history of MTC or MEN 2 syndrome
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An imbalance in gut bacteria can lead to decreased GLP-1 production, contributing to increased hunger and cravings, making weight loss more challenging
The present update preserves the hierarchy for weight-loss efficacy while adding direct comparative evidence from SURMOUNT-5 and substantially more complication-specific randomized data (Aronne 2025)
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