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Functional factors that simultaneously improve both outcomes act through reducing oxidative stress via the Nrf2Keap1ARE network, regulating energy metabolism via the PI3K/Akt/mTOR and AMPK pathways, suppressing NF-B-mediated inflammation, and optimizing the gutlivermuscle axis
Considering that around one-third of the global population and 42.4% of US adults are classified as obese, these medications have a significant market [6, 7]
Thereby, the subcellular compartmentalization would be critical to minimize the excess cellular toxicity while rendering its metabolic outcomes or benefit
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