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Novo Nordisk's investment in prescriber education and patient support programs, combined with copay assistance initiatives that reduce out-of-pocket costs for commercially insured patients, has sustained Ozempic's prescription volume even as the market has expanded

Nevertheless, the beneficial testicular effects of these emerging therapies appear to vary according to basal levels of androgens, as emerged in a recent prospective cohort study where the exenatide-based therapy did not significantly change FT levels in diabetic men without hypogonadism [159] , thus supporting a relevant role of incretin mimetics on male HPG axis, particularly in hypogonadism

Multimodal physical therapy programs that combine muscle training, education, and physical activity have also shown strong improvements in symptoms and quality of life, with high patient satisfaction and no reported safety concerns