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Furthermore, glutathione is expected to act on the type of melanin that is produced, commending the synthesis of pheomelanin (which has a pink to yellow hue) over eumelanin (which is brown to black), allowing lighter skin tones with satisfactory outcomes
Finally, Lys212 forms a Schiff base with PLP to restore the resting state (Figure 5) (Sun et al., 2009
In line with this observation, our comprehensive transcriptome analysis of paired tumor specimens obtained before (PreNAC) and after (PostNAC) CF-based NAC revealed that 14 GSH metabolismrelated genes were highly expressed in recurrent tumors at the PreNAC stage, the PostNAC stage, or both, supporting the notion that resistance-associated molecular programs are often established prior to chemotherapy rather than being broadly acquired during NAC
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