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A 24 h fasting period of WT or ob/ob mice, upregulated PPAR and PPAR-target genes related to mitochondrial (medium- and long-chain acyl-CoA dehydrogenases), peroxisomal (acyl-CoA oxidase (ACOX) 1 and enoyl-CoA hydratase), and cytochrome-mediated (CYP4A1 and CYP4A3) FAO [85]
We showed that blocking GGT activity slows tumour growth by depriving it of intracellular cysteine
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