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Health concerns stemming from the excessive accumulation of body fat constitute the definition of obesity, which is a recognized medical state
Effect of Weekly Subcutaneous Semaglutide vs Placebo on Body Composition in Adults With Overweight or Obesity
This partnership was the first time an FDA-cleared weight management aid or primary care product was made available at launch nationwide via telehealth providing immediate access to patients regardless of insurance status, zip code, or provider availability in their area
Sitagliptin, a dipeptidyl peptidase-4 inhibitor, was selected as an active-comparator placebo proxy because it was recommended in clinical guidelines as a second-line glucose-lowering therapy, had a similar high cost to the study drugs, showed no effect on cardiovascular outcomes in a large randomized controlled trial and has been validated as a placebo proxy in prior claims-based research 20,41
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