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The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)
Funding This work was supported by the Zhejiang Provincial Natural Science Foundation of China (LTGY24H030002), the National Key R&D Program of China (2022YFA1105603 and 2022YFC2304405), the Fundamental Research Funds for the Central Universities (2025ZFJH03 and 2022ZFJH003), the Zhejiang Provincial Key Research and Development Program (2019C03015), and the Shandong Provincial Laboratory Project (SYS202202)
Its the final line of defence, neutralizing free radicals, repairing oxidized proteins, and recycling other antioxidants