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A Seahorse XFe96 Analyser (Agilent Technologies) was used to assess mitochondrial complex-specific OCR of HCT116 CRC cells
However, these compounds have thus far not had been subjected to clinical trials, possibly because of unwanted side effects, including lower Ca 2+ transport or increased heme-oxygenase (HO-1) levels (Konorev et al., 2002)
most cases appear to be sporadic, in which both genetic and environmental risk factors play a role 7 , while a small proportion arise from monogenic mutations
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