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Administering these vitamins via injection bypasses gastrointestinal absorption barriersuseful for patients with pernicious anemia, post-gastrectomy states, chronic metformin or acid-suppressing therapy that impairs B12 absorption, or conditions that reduce intestinal uptake
Cysteine is the rate-limiting amino acid for GSH biosynthesis
For some patients a single peptide is the better starting point
Intervention studies with glutathione precursors (particularly cysteine and glycine) show improvements in insulin sensitivity and mitochondrial function in older adults
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