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The dual roles of IL-1 in PD appear to reflect differences in signalling intensity and persistence, whereby chronic elevation is associated with neurodegenerative outcomes, whereas transient or low-level activation may be compatible with homeostatic or protective immune functions

Edited by Lin LY, Lei Y Acknowledgements The authors would like to thank to Universitas Hasanuddin for providing financial support under Penelitian Fundamental Kolaboratif (PFK) (00323/UN4.22/PT.0103/2023), and highest appreciation to the National Research and Innovation Agency (BRIN) and World Class University Program, Indonesia Endowment Fund for Education, Universitas Diponegoro

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