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Additionally, 5-HT exerts both anti-inflammatory and pro-inflammatory effects under intestinal inflammatory conditions by binding to different receptors, and demonstrates biological functions in systems beyond the gut, such as in autism and depression

Researchers believe this is due to increased ROS (increased oxidative stress) in the pancreatic beta cells.[ref] Related article : Type 2 Diabetes Genes Fatty liver disease: High homocysteine levels are associated with NAFLD (fatty liver disease, MAFLD)