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Rather than identifying definitive diagnostic biomarkers, this study highlights a small number of metabolitesmost notably leucine, betaine, and coumarinthat may contribute to metabolic stratification of ASD in future work
The mechanism leading to 5-oxoprolinuria is the following: decreased activity of 5-oxoprolinase leads to decreased conversion of 5-oxoproline to glutamate
7 This presents the idea that GLP-1 RAs exert effects beyond weight loss or glycemic control, perhaps acting locally on immune cells or keratinocytes
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