[4] Cold is most effective at relieving pain and swelling during the first 3 days after the injury, but after that, using heat can help relax the area and may increase circulation, which can promote healing

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It binds and unbinds in a constant exchange, so some free copper ions escape and irritate local nerve endings while activating mast cells (immune cells that release histamine and trigger inflammation)
Some discomfort during or after your at home B12 injection is perfectly normal, but there are simple ways to manage it