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Earlier secretagogues such as GHRP-6 and GHRP-2 do trigger GH release, but they also switch on other pathways: they can raise cortisol (a stress hormone), raise prolactin, and drive a strong hunger response

Psychosocial stress and overweight and obesity: findings from the Chicago Community Adult Health Study

However, most available randomized data derive from subgroup, post hoc, or exploratory analyses rather than trials specifically designed to evaluate dual therapy in HF populations

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