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These medications work through different but related mechanismssemaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, while tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist
According to the Washington Post, research shows that some people respond more slowly than others, and several factors can affect how well these medications work
Both obesity and migraine involve elevated pro-inflammatory markers, and the same cytokines that drive systemic inflammation in obesity appear to lower the threshold for migraine attacks by sensitizing pain pathways in the trigeminal nervous system
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