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In the STEP 1 trial, semaglutide 2.4mg produced an average body weight reduction of approximately 14.9% at 68 weeks in people with obesity

Patients who are also suffering from gastrointestinal disorders, such as small intestinal bacterial overgrowth (SIBO), Celiac or Crohns may not be absorbing Vitamin B12 optimally due to an underlying inflammatory load and unfavourable microbiome

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In bone, GLP-1 binding to its receptor promotes bone marrow mesenchymal stem cell osteoblast differentiation and inhibits its differentiation into fat cells, thereby promoting bone formation and improving osteoporosis [15]