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Seek urgent medical attention via NHS 111, your GP, or A&E if muscle pain is severe, persistent, or accompanied by weakness, dark urine, or significant functional impairment, as these may indicate serious conditions like rhabdomyolysis

Incretin Physiology GLP-1 is made and released by the enteroendocrine L-cells, which are found throughout the small and large intestines, with higher concentration in the ileum

By activating GLP-1 receptors, retatrutide enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, and reduces appetite