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A key driver of neuronal injury is oxidative stress, which arises when the generation of reactive oxygen species (ROS) overwhelms the brains antioxidant defenses, one such defense being glutathione (GSH) (Dringen and Arend, 2025)

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The role of GLP-1 receptor agonists in opioid addiction is still under investigation, but initial studies suggest that these drugs could reduce the rewarding effects of opioids, making them less appealing to users

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