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2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer
Although critical glutathione levels will lower as we age, depletion can be accelerated by stress, illness, infection, poor diet, alcohol, cigarettes, trauma, and environmental toxins
Mechanism-informed patient selection Biomarker-based stratification: Identifying patients most likely to respond based on mechanistic markers
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